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- SwiSwi
- SwiSXY
- SySyl
- SylSym
- SymSyn
- SynSZA
- SZAszy
- Sebghati, Houman (Swedish Rapper)
- Sebia (Greek hard rock group)
- SEBii (hyperpop producer/rapper from Shanghai)
- Sebina, Mpho
- Sebjak
- Sebó (Sebastian Bosum)
- Sebo & Madmotormiquel & Nayan Soukie
- Sebo & Madmotormiquel & Soukie, Nayan
- Sebo, Madmotormiquel & Soukie, Nayan
- Sebutones
- Secada, Jon
- Secada, Jon · Pavarotti, Luciano
- Secada, Jon & Pavarotti, Luciano
- Secada, Jon & Shanice
- Secada, Jon and Shanice
- Secchi
- Secchi, Emiliano
- Secchi, Stefano (Italian DJ/producer, aka Secchi)
- Secchi, Stefano feat. Taleesa
- Secchin, Julio
- Secchin, Julio & Rebeca
- Secession
- Secession, The
- Sech
- Sech feat. Mozart la Para & Farina
- Sech, Mora & Saiko
- Sechem
- SECHSKIES
- Seck, Cheick Tidiane
- Seck, Djeneba
- Seck, Thione
- Seck, Wally
- Seckond Chaynce
- Secluded, The (rock band)
- Secoli Morti
- Secombe, Harry
- Second (Spanish band)
- Second Act (key track: 'Natural High')
- Second Band, The
- Second Chance Blown
- Second Chance, A (US rock band renamed to Just Surrender)
- Second City
- Second Civil (Artis SMM Records)
- Second Class
- Second Combat
- Second Come (Brazilian band)
- Second Coming (hardcore, ca, usa)
- Second Coming (US rock/industrial band)
- Second Coming, The (early incarnation of "The Allman Brothers Band")
- Second Complex feat. Color Theory
- Second Date
- Second Decay (German wave band)
- Second Hand (British 60's prog/psych)
- Second Hand High
- Second Identity (A-lusion & Scope DJ)
- Second Identity Ft. Chucky, MC
- Second Layer
- Second Nature (Hardcore/Punk from Vancouver)
- Second Person
- Second Sex
- Second Still (gothic rock)
- Second Sun
- Second Sun (Progressive psychedelic trance project based in Denmark)
- Second Thief
- second thoughts (British indie pop group based in Hitchin)
- second thoughts & House Pet
- Second to Sun
- Second Voice
- Second-Hand Apes
- Seconday (Bulgarian rock band)
- Secondcity
- Secondcity & Rowe, Tyler
- Secondcity feat. Love, Ali
- Secondhand Saints (Belgian metalcore band)
- Secondhand Serenade
- Secondhand Serenade feat. Ballestrini, Veronica
- Secondhand Sound
- Seconds Before Landing (US Prog Group)
- Seconds Flat
- Secondshot (Punk Rock Band)
- Secondspring
- Secondtunez
- Secondwall
- Secos & Molhados
- Secoya (Dubstep)
- Secret
- Secret (South Korean girl group)
- Secret Affair
- Secret Agent (surf band from Mexico)
- Secret Agent 23 Skidoo
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