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- SwiSwi
- SwiSwo
- SwoSyb
- SycSyl
- SylSyn
- SynSyr
- SyrSzc
- Szcszy
- Spider and the Webs
- Spider Bags
- Spider Harrison
- Spider Lilies
- Spider Loc
- Spider Murphy Gang
- Spider ZED (Rappeur français membre du High Five Crew)
- Spider, Dried
- Spiderbait
- Spidergawd (Norwegian hard rock band)
- Spiders (Swedish hard rock band)
- Spiders (dubstep/experimental artist)
- Spiders & Snakes
- Spiders From Mars, The (Eurobeat group)
- Spiders, The (1970s Mexican psychedelic rock band)
- Spiders, The (1950s New Orleans R&B vocal group)
- Spids Nøgenhat (Danish psychedelic rock band)
- Spiegel, Sam & Tropkillaz feat. BIA & Pikachu, MC
- Spiegel, Sam feat. Anderson Paak & Doja Cat
- Spiegel, Sam feat. Bipolar Sunshine
- Spiegel, Sam feat. Sia, Busta Rhymes & Mensa, Vic
- Spielbann
- Spielberg, Robin
- Spielbergs (indie rock)
- Spielmann, Lisa (pop artist)
- Spier, Bernd (German schlager singer and record producer)
- Spiers & Boden
- Spies Like Us (metalcore from NH)
- Spieß, Chris
- Spięty (Hubert Spięty Dobaczewski)
- Spiff TV feat. Prince Royce & Brown, Chris
- Spiffy Man (American producer, Steven John Alvarez)
- Spigt, Frédérique (Dutch singer)
- Spiha
- Spike (UK singer/songwriter, member of Quireboys)
- Spike (euro house, Barrelhouse J.M. & Pamela Mitchell)
- Spike (Romanian singer)
- Spike (My Little Pony: Friendship Is Magic character)
- Spike (Polish disco)
- Spike 1000
- Spike and Tyla’s Hot Knives
- Spike Fuck
- Spike Hellis
- Spike Universe (hip-hop/urban artist from Sri Lanka)
- Spike, DJ (Keith LeBlanc)
- Spikes, The
- Spikey Wikey
- Spilker, Frank, Gruppe
- Spill Canvas, The
- spill tab
- spill tab & Genesis, Tommy
- spill tab & JAWNY
- Spill Your Guts
- Spillage Village
- Spillane, Davy (Irish songwriter & musician of uilleann pipes, low whistle.)
- Spillane, John
- Spillane, Sean
- Spiller (Italian DJ Cristiano Spiller, known for "Groovejet")
- Spiller feat. Ellis-Bextor, Sophie
- Spiller feat. Ellis‐Bextor, Sophie
- Spiller, D’Arcy
- Spills, The
- Spillsbury (German electropop band)
- Spilly Cave (Harrisburg, PA, USA)
- Spilt image (Crossover/Thrash from California)
- Spilt Milk Society
- Spilverk þjóðanna
- SPiN (American Rock Band from Philadelphia, PA)
- Spin (Dutch jazzrock group)
- SPIN (romanian rock band)
- Spin 1ne 2wo
- Spin Doctors
- Spin Doctors feat. Markie, Biz
- Spin Gallery
- Spin My Fate
- Spin Twice (Tina Šetkić, Augustin Bauer, Thomas Smagghe)
- Spin Wires, The
- Spin‐Up
- Spinabenz
- Spinabenz & Whoppa Wit da Choppa
- Spinache (Polish rapper)
- Spinal & Steen
- Spinal Cord (Polish metal band)
- Spinal Tap
- Spinall (Nigerian)
- Spinanes, The
- Špinarová, Věra
- Spindle (unknown artist)
- Spindrift (psychedelic western band from California)
- Spinebreaker (US Death Metal/Hardcore)
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