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- SwiSwo
- SwoSyb
- SycSyl
- SylSyn
- SynSyr
- SyrSzc
- Szcszy
- Sparrow Sleeps
- Sparrow-Folk (glam-folk)
- Sparrow, Alex
- Sparrow, Alison
- Sparrow, Jack (Leeds based dubstep producer)
- Sparrow, Ryan (UK Artist)
- Sparrows (Indie pop artist from Sydney, Australia)
- sparsevector
- Sparta (American rock band)
- SPARTA (Japanese hip-hop)
- SPARTA LOCALS
- Sparta, Tommy Lee
- Spartan (track "Cracks")
- Spartan (Dutch melodic death metal band with mythological lyrical themes)
- Spartan Jet-Plex
- Spartan Warrior
- Spartano, Jessie
- Spartiti
- Sparx (Mexican-American pop group)
- Sparxxx, Bubba
- Sparxxx, Bubba feat. Attitude
- Sparxxx, Bubba feat. Backbone & Brown, Sleepy
- Sparxxx, Bubba feat. Big Rube
- Sparxxx, Bubba feat. Brown, Sleepy
- Sparxxx, Bubba feat. C.I.
- Sparxxx, Bubba feat. Cook, Kyle, Boone, Danny & Jones, Demun
- Sparxxx, Bubba feat. Crucifix
- Sparxxx, Bubba feat. Dean, Kiley
- Sparxxx, Bubba feat. i4Ni
- Sparxxx, Bubba feat. J, Frankie
- Sparxxx, Bubba feat. Ken, Duddy
- Sparxxx, Bubba feat. Killer Mike & Cool Breeze
- Sparxxx, Bubba feat. Killer Mike and Cool Breeze
- Sparxxx, Bubba feat. Pablo, Petey and Brown, Sleepy
- Sparxxx, Bubba feat. Scar
- Sparxxx, Bubba feat. Sebastian
- Sparxxx, Bubba feat. Tedder, Ryan
- Sparxxx, Bubba feat. Timbaland
- Sparxxx, Bubba feat. Ying Yang Twins & Collipark, Mr.
- Sparxxx, Bubba feat. Ying Yang Twins and Collipark, Mr.
- Sparzanza
- Spasiuk, Chango (Chamamé Argentine composer and accordionist)
- Spastic Ink
- Spătaru, Dan (Romanian schlager singer)
- Spatial Distortion (ambient-electronic)
- Spatial Relations
- Spätregen
- Spats, The (Mid-60s California garage rock band)
- Spats, The (Australian rock'n'roll)
- Spaulding (Pop Punk artist based in Karlsruhe, Germany.)
- Spaulding, Henry
- Spauls Brothers
- Spauls, Leo
- Spaven, Richard
- Spaven, Richard feat. Rakei, Jordan
- Spawn (German death metal band)
- Spawn (Ska band from the Netherlands)
- Spawn of Possession
- Spawnbreezie
- Spawnbreezie feat. Big Steve
- Spax (German Rapper)
- Spax feat. Massive Töne
- Spaze
- Spaze Windu
- Spazz
- Spazztic Blurr
- Spazzys
- SPC ECO
- Speace, Amy
- SpeaK (netlabel musician)
- Speak (Austin pop rock band)
- Speak Low (American Artist)
- Speak Low If You Speak Love
- Speak No Evil (US hard rock/nu metal band)
- Speak the Truth… Even If Your Voice Shakes
- Speak, Brother
- Speakeasies' Swing Band, The
- Speakeasy Three, The
- Speaker 66 (Electronic)
- Speaker Honey
- Speaker Knockerz
- Speaker Knockerz feat. Young Dolph & Guapo, Jose
- Speaker Speaker
- Speakers Corner Quartet
- Speakers Corner Quartet feat. Confucius MC & Armon‐Jones, Joe
- Speakers Corner Quartet feat. Lafawndah & TRUSTFALL
- Speakers Corner Quartet feat. LEILAH
- Speakers Corner Quartet feat. Massiah, James
- Speakers Corner Quartet feat. Sampha
- Speakers Corner Quartet feat. Sen, Léa
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