- Unzane
- Unzucht
- Uochi Toki (Italian hip-hop band)
- Uomini in frac
- Uoti, Henna
- Up & Down
- uP & pG
- Up Close
- Up dharma Down
- Up Dharma Down
- Up From Here
- Up Front
- Up Hygh
- Up Up Down Down Left Right Left Right B A Start
- Up Up Girls (Kari)
- Up With People
- UP-BEAT
- Up, Ari
- Up, Bustle & Out
- UP! (Hungarian band)
- UP10TION
- UPA Dance
- Upa!
- Upadhyay, Purushottam
- UPAFTER, The
- Upbeats, The (New Zealand drum n bass duo)
- Upbeats, The (50s US group)
- Upbeats, The feat. Baxter, Tasha
- Upbeats, The feat. Joe Dukie
- Upbeats, The feat. Mara TK
- Upbeats, The feat. Worboys, Ned
- Upchuck (Atlanta punk)
- Upchurch (country rapper)
- Upchurch feat. Mama Church
- Upchurch feat. Merkules & Jelly Roll
- Upchurch, Phil
- Upchurch, Phil, Combo
- updog
- Upercent (house)
- Upfront
- Upfux, The (New Jersey Ska band)
- Upgrade (NY hip-hop)
- Upgrade (Psychedelic trance duo from Israel [Raz Kfir & Udi Pilo])
- Uphill Battle
- Upiór
- Upjohn, Jed
- Uplift, Ori
- Uplink (house)
- Upon a Burning Body
- Upon a Red Sky
- Upon the Water (Metalcore Band)
- Upon This Dawning
- Uponcue
- Upper Class (house duo, active around the turn of the millennium)
- Upper Crust, The (U.S. hard rock band from Massachusetts)
- Upper Room, The
- Upper Structure
- Upper Tunist, The
- Upper West
- UPPERCASE
- Uppermost
- UPPERROOM
- UPPERROOM, Figueroa, Joel
- UPPERROOM, Gamboa, Abbie
- UPPERROOM, Mauldin, Meredith
- UPPERROOM, Smith, Elyssa
- UPPERROOM, Smith, SarahBeth
- Uprise, The (Canadian band)
- Uproar (UK Trance - Also known as: BCD Project, Hardnox, King Of Clubs)
- UPSAHL
- UPSAHL & Absofacto
- UPSAHL feat. blackbear
- UPSAHL feat. Two Feet
- Upset (US band, formed 2013)
- Upset Victory, The (American Rock Band)
- Upsetter (Brisbane punk band)
- Upsetters, The (Lee Perry's reggae house band)
- Upshaw, Dawn (soprano)
- Upside Down Room
- Upsided, The
- Upsidedown Cross
- Upsidedown, The
- Upsilon (French rapper)
- Upsilone
- Upstairs, The (Indonesian rock band)
- Upstanding Youth
- Upstartz
- Upstrz (r&b singer/songwriter)
- Upton, Jason
- Upton, Pat
