- Uplift, Ori
- Uplink (house)
- Upon a Burning Body
- Upon a Red Sky
- Upon the Water (Metalcore Band)
- Upon This Dawning
- Uponcue
- Upper Class (house duo, active around the turn of the millennium)
- Upper Crust, The (U.S. hard rock band from Massachusetts)
- Upper Room, The
- Upper Structure
- Upper Tunist, The
- Upper West
- UPPERCASE
- Uppermost
- UPPERROOM
- UPPERROOM, Figueroa, Joel
- UPPERROOM, Gamboa, Abbie
- UPPERROOM, Mauldin, Meredith
- UPPERROOM, Smith, Elyssa
- UPPERROOM, Smith, SarahBeth
- Uprise, The (Canadian band)
- Uproar (UK Trance - Also known as: BCD Project, Hardnox, King Of Clubs)
- UPSAHL
- UPSAHL & Absofacto
- UPSAHL feat. blackbear
- UPSAHL feat. Two Feet
- Upset (US band, formed 2013)
- Upset Victory, The (American Rock Band)
- Upsetters, The (Lee Perry's reggae house band)
- Upshaw, Dawn (soprano)
- Upside Down Room
- Upsidedown Cross
- Upsidedown, The
- Upsilon (French rapper)
- Upsilone
- Upstairs, The (Indonesian rock band)
- Upstanding Youth
- Upstartz
- Upstrz (r&b singer/songwriter)
- Upton, Jason
- Upton, Pat
- Uptones, The
- Uptown (Brooklyn rapper Raie Dacosta)
- UPTOWN BOYBAND
- Uptown Funksters, The
- Uptown Lokolz (Bangladeshi rap gang)
- Uptown Monotones, The
- Uptown Players, The (jazz band)
- Uptown X.O. feat. A.B. the Producer
- Upwelling, The
- UQiYO
- ur pretty (Pop-punk side project of Jake Hill)
- Ural Thomas
- Ural Thomas and The Pain
- Ural, Kıvılcım
- Uran, Boris (Austrian Popstar)
- Uranienborg Vokalensemble
- Uranium 235 (New York electronic band)
- Uranium Club (Minneapolis punk band)
- Uranium Mind (Australian trance/electronic artist Julian Jansen)
- Urarv (Avant-garde Black Metal from Norway)
- Uras, Fulden
- Urata, Nick (American score composer)
- Uraz, Server
- Urba y Rome (reggaeton producers, aka Los Evo Jedi)
- Urbain
- Urban & 4
- Urban Assault (Electronic)
- Urban Astronauts
- Urban Astronauts Feat. Smith, Kate Louise
- Urban Cone
- Urban Cone feat. Tove Lo
- Urban Cookie Collective
- Urban Dance Squad (Dutch rap rock band)
- Urban Delights
- Urban Dogs
- Urban Dub (UK group)
- Urban Graveyard
- Urban Guerillas (Australian pub rock band)
- Urban Heat (Texas post-punk band)
- Urban Heroes
- Urban Jazz Network
- Urban Knights
- Urban Monk (chilean alternative rock band)
- Urban Mystic
- Urban Myth Club
- Urban Rescue
- Urban Soul (house music production alias of Roland Clark)
- Urban Species
