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- IaniCa
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- IcoIdi
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- IglIGO
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- IsaIsc
- iScIsl
- IslIso
- IsoIst
- IstIto
- ItoIve
- IveIwa
- IwaiZe
- IzeIzz
- Isaac (hardstyle artist)
- Isaac Adni
- Isaac Delusion (French pop band)
- Isaac et Nora
- Isaac Green And The Skalars
- Isaac Joseph Santosh Gomez (Australian Artist)
- Isaac la Voz
- Isaac Stuart
- Isaac Zale (fka Zac Flewids)
- Isaac, DJ (hardcore/hardstyle DJ & producer)
- Isaac, DJ feat. Wildstylez
- Isaac, Evan (2020s New York singer-songwriter)
- Isaac, Greta
- Isaac, Heinrich (Flemish Renaissance composer)
- Isaac, Ismaël
- Isaac, Jake
- Isaac, Jamie (bedroom producer)
- Isaac, Sam
- Isaac, Tommy
- Isaacs Bowman, Becky
- Isaacs, Bud
- Isaacs, David
- Isaacs, Gregory
- Isaacs, Gregory & Brown, Dennis
- Isaacs, Pamela
- Isaacs, Pamela, White, Lillias
- Isaacs, Sonya (American country and Christian music singer)
- Isaacs, The
- Isaacson, Ella
- Isaak (trance act)
- Isaak, Chris
- Isaak, Chris duet with Yearwood, Trisha
- Isaak, Chris with Branch, Michelle
- Isabel (German pop vocalist Isabel Soares)
- Isabel Aaiún (Spanish, 2021)
- Isabel Dumaa
- Isabel Marco
- Isabel Suckling (vocal)
- Isabel, Sandra
- Isabela (Isabela, cantante sinaloense)
- Isabell Schmidt
- ISABELLA (Isabella Peschardt)
- Isabella, Kira
- Isabelle A (Belgian singer, Isabelle Adam)
- Isabelle Brown
- Isabelle, Ana
- Isabellea
- Isacaarum (Czech grindcore)
- Isacowitz, Maya
- Isacsson, Pierre
- Isadar
- Isador (Warren Heller)
- Isadora (pop/soul/jazz singer)
- Isai Morales (Male solo artist)
- ISAIAH (rapper)
- Isaiah Ardie Greenwood
- Isaiah Falls
- Isaiah, Cameron (artist, lyricist)
- Isaiah, Daniel
- Isaiah, Zion
- Isak (Swedish singer-songwriter born in the 1970s)
- Isak (fuzz/stoner rock band from Glasgow, Scotland)
- ISÁK (Norwegian band focusing on Sami music; appears on "Lonely")
- Isak Strand vs. TOE
- Isakoatl
- Isakov, Gregory Alan
- Isaksson, Patrik
- Isaksson, Patrik & Dawn Finer, Sarah
- Isaksson, Patrik & Dea
- Isaksson, Patrik & Sjöholm, Helen
- Isaksson, Patrik, Moraeus, Kalle & Jansson, Bengan
- Isam B (Danish singer of Moroccan descent)
- ISAN
- Isasa (Spanish composer, guitarist)
- Isatha
- isaur
- Isaurian
- Isayama, Mio
- Isbell, Jason
- Isbell, Jason & 400 Unit, The
- Isbell, Jason & Shires, Amanda
- Isbell, Jason and 400 Unit, The
- Isbell, Jason and the 400 Unit
- Isbell, Jason and the 400 Unit feat. Fleck, Béla & Thile, Chris
- Isbell, Jason and the 400 Unit feat. Shires, Amanda
- Isbell, Jason and the 400 Unit feat. Spencer, Brittney & White, John Paul
- Isbells (Belgian indie/neofolk group)
- Isbin, Sharon (classical guitarist)
- Isbjörg
- Ischi, Takeo