- Irony of Fate (Switzerland, Metal)
- Irrational
- Irrational (Orlando, Florida based rock band)
- Irrelevant (Australian punk band)
- Irrenoffensive
- Irrepressibles, The
- Irrésistibles, Les
- Irresponsibles, The (From Adelaide, South Australia)
- Irreversible Entanglements
- Irreversible Mechanism
- IRRIS (South Korean girl group)
- Irrlicht
- Irrlichter, Die
- Irrlycht (German black metal)
- Irrwisch
- Irrwisch (Netherlands / Black Metal)
- IRS, The (UK rap group)
- IRU (Georgian pop singer Iru Khechanovi)
- irucaice
- IRUKA
- Irusta, Agustín
- Iruviya
- Irvine, Andy
- Irvine, Andy & Brady, Paul
- Irvine, Jeremy, James, Lily, Brosnan, Pierce & Seyfried, Amanda
- Irvine, Weldon
- Irving
- Irving Aaronson
- Irving Casanova (Regional Mexican)
- Irving Manuel
- Irving, Amy
- Irving, Catriona
- Irving, Lonnie
- Irwansyah
- Irwin, Ashton
- Irwin, Big Dee
- Irwin, Big Dee & Little Eva
- Irwin, Fred
- Irwin, Richard M.S.
- Irwin, Russ
- Irya's Playground
- IRyS (hololive EN Project: HOPE)
- Is (Spanish indie pop)
- Is (Black Metal from Russia)
- IS TROPICAL
- IS U IS U (Kito & Chrome Sparks)
- Is/Is
- Is0kenny (New Jersey rapper)
- Isa (Swedish singer Isa Tengblad)
- Isa Glücklich
- Isa Izquierdo
- Isa TKM (Nickelodeon TV Series)
- Isaac (hardstyle artist)
- Isaac Adni
- Isaac Delusion (French pop band)
- Isaac et Nora
- Isaac Green And The Skalars
- Isaac Joseph Santosh Gomez (Australian Artist)
- Isaac la Voz
- Isaac Stuart
- Isaac Zale (fka Zac Flewids)
- Isaac, DJ (hardcore/hardstyle DJ & producer)
- Isaac, DJ feat. Wildstylez
- Isaac, Evan (2020s New York singer-songwriter)
- Isaac, Greta
- Isaac, Heinrich (Flemish Renaissance composer)
- Isaac, Ismaël
- Isaac, Jake
- Isaac, Jamie (bedroom producer)
- Isaac, Sam
- Isaac, Tommy
- Isaacs Bowman, Becky
- Isaacs, Bud
- Isaacs, David
- Isaacs, Gregory
- Isaacs, Gregory & Brown, Dennis
- Isaacs, Pamela
- Isaacs, Pamela, White, Lillias
- Isaacs, Sonya (American country and Christian music singer)
- Isaacs, The
- Isaacson, Ella
- Isaak (trance act)
- Isaak, Chris
- Isabel (German pop vocalist Isabel Soares)
- Isabel Aaiún (Spanish, 2021)
- Isabel Dumaa
- Isabel Marco
- Isabel Suckling (vocal)
- Isabela (Isabela, cantante sinaloense)
- Isabell Schmidt