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- SwiSwi
- SwiSwo
- SwoSyb
- SybSyl
- SylSym
- SymSyn
- SynSys
- SysSz
- Szeszy
- Syskofrenia (Finnish jazz band)
- System (Minimal IDM on ~scape records)
- System (UK)
- System 7 (UK electronic dance music band)
- System Divide
- System F
- System F feat. Almond, Marc
- SYSTEM ghost
- System Nipel (Psy-Trance duo from Beer Sheva, Israel, both of Russian origin. Emigrated to Israel during the 90's)
- System Noise
- System of a Down
- System Olympia
- System Shock (Swedish metal band)
- System Syn
- System X (Dance/Rock)
- system-B (Japan)
- System, Gultrah Sound
- System, The (80s UK synthpop band)
- System, The (80s US synth band)
- Systema Solar
- Systema Solar feat. Bouizzoul, Nedjim
- Systema Solar feat. Fahima, Oshrat / Torres, Carmelo
- Systema Solar feat. Harry, Deborah
- Systema Solar feat. La-33
- Systemabsturz
- Systematic (US hard rock band)
- Système Crapoutchik, Le
- Systeme Paradoxe
- Systemet
- Systemfehler
- Systemia
- Systemik Viølence
- Systems in Blue
- Systems Officer
- Systems, Steel
- Syster Sol
- Syster Sol feat. Aki, Dani M & General Knas
- Syster Sol feat. Promoe
- Systur (Sigga, Beta & Elín)
- Systylé
- Sysyphe (Electronic music artist)
- SYTË
- Syteria (Jackie Chambers from Girlschool)
- sytokene
- Syu (metal guitarist)
- syudou
- Syvia
- Syzo, Rob
- Syzy (dubstep)
- Syzygy (Progressive Rock from Ohio)
- Syzz
- SZ
- SZA
- SZA & Harris, Calvin
- SZA & Lamar, Kendrick
- SZA & Timberlake, Justin
- SZA feat. Bridgers, Phoebe
- SZA feat. Chance the Rapper
- SZA feat. Don Toliver
- SZA feat. Fauntleroy, James
- SZA feat. Lamar, Kendrick
- SZA feat. Ol’ Dirty Bastard
- SZA feat. Rashad, Isaiah
- SZA feat. Scott, Travis
- SZA with Lamar, Kendrick
- Szabo Balazs Bandaja (Szabo Balazs Band)
- Szabó Benedek és a Galaxisok
- Szabó Eszter
- Szabo, Adam (Hungarian electronic musician)
- Szabó, Gábor
- Szabo, Seb
- Szachniuk, Nadia
- Szad (polish MC, member of Trzeci Wymiar)
- Szafran, Justyna
- Szakács, Gergő
- Szakcsi
- Szalóki Ági
- Szałapak, Anna
- Szandi
- Szarmach, Ania
- Szászcsávás Band
- szatt (Łukasz Palkiewicz; beatmaker part of Himalaya Collective)
- Szczepanek, Charles (Pianist)
- Szczepaniak, Ada
- Szczepanik, Piotr
- Szcześniak, Mietek
- Szczygieł, Michał (Polish vocalist and lyricist)
- Szczyl
- Szczyl & Magiera
- Szécsi, Pál
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